Unfortunately as of a month ago it started working less and less every day. The exact abnormality leading to urethral sphincter mechanism incompetence and the region of the urethra in which it occurs are unknown. WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of 5. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. Georgie is otherwise a healthy, active girl with no other health issues. Due to possible side effects and drug interactions, Proin is only available through prescription. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. Have never heard of Incurin..but one of the vets I work with routinely uses DES and at the end of decreasing dose. With Proin it has largely been a non issue. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls.8 Similarly, a study measuring urethral pressure profiles and continence scores of incontinent dogs with USMI showed that phenylpropanolamine was significantly more effective than its analog, pseudoephedrine, at increasing maximum urethral closure pressure and functional area as well as continence score.1, Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs.12 Maximal concentrations (Cmax) are reached 2 hours after administration, with a half-life of 3 to 4 hours for the immediate-release formulation.8,12 Phenylpropanolamine absorption in the controlled-release formulation is biphasic, with a rapid initial absorption phase followed by a second slower absorption phase that continues for up to 16 hours.12 Pharmacokinetic studies of Proin ER showed a slightly higher Cmax than Proin; however, overall drug exposure (area under the curve) was less.5 Phenylpropanolamine is primarily excreted unchanged by the kidneys.12. If your concern is whether it is safe to use both meds together, I can only speak from my experience but that was a vet-prescribed regimen that worked safely for my dog. 5. Copyright 2023 PetMed Express, Inc. All Rights Reserved. 15% discount available for new customers only. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. Dog Pet Animals and Pets . Were sorry, but our website doesnt work properly without JavaScript enabled. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. Visit PetMeds to save on Incontinence. Please be aware that estriol and phenylpropanolamine products should not be imported from other countries for use in animals. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. 8. I believe it's been used in Europe for a while and seems to be safer than DES. (1996) Urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of 54 cases. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Veterinarians.org does not intend to provide veterinary advice. I think i am leaning towards the DES so far, but i have yet to ask my vet about that one. Before treatment can be contemplated, an understanding of the pathophysiology of urethral sphincter mechanism incompetence is required. 1. Greytalk.com Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge"Always do sober what you said you'd do drunk. 9. Worked great. Byron JK, March PA, Chew DJ, DiBartola SP. Press question mark to learn the rest of the keyboard shortcuts. 2007;21(1):47-53. She started leaking urine when would lay down about 3 years ago. Proin chewable tablets. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. As in the bitch, the acquired form often follows neutering and larger breeds appear to be at risk. 5. Dr. Snell received her DVM from Texas A&M University and has completed a rotating internship at Louisiana State University. Proin does not work for dogs with urinary incontinence due to other medical conditions like malformations and neurologic disease. Similarly, increasing urethral length carries potentially serious surgical risks and, in the author's view, should be reserved for animals with severe congenital urethral hypoplasia. 2. In other words, Pehnylpropranolamine works by constricting the bladder sphincter muscle, thus preventing urine leakage. New comments cannot be posted and votes cannot be cast. The treatment of cases of sphincter mechanism incompetence may be difficult and most therapies correct only one of the above factors. NADA 141-325. Do not give OP specific treatment instructions, including instructions on meds and dosages. J. small Anim. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. , but the issue is not confirmed in pets. In humans and certain animal species, sympathomimetic drugs are linked with. WebThe use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year. Clark JH, Hardin JW, McCormack SA. My dog takes Incurin 1mg tablets. 7. Care is taken to avoid compression of the urethra during the technique. -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter. The vet will determine the dogs usual dose. 21. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. While not reported in companion animal species, the use of sympathomimetic drugs, including phenylpropanolamine, has been associated with birth defects in people, rabbits, and chickens.14,15 Safety studies in this population of companion animals are lacking; therefore, therapy with phenylpropanolamine should be avoided in pregnant or lactating bitches. We never reprimanded her for it of course, since she couldn't help it, but she would often try to lick the spot on her bed to cover up the evidence. PRN Pharmacal. 15. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Used hospital pads. By CBMB on Nov 3, 2022 Incurin worked This worked within three days. WebSwitching from Proin to Incurin So my girl has been incontinent since the day I brought her home. Our dog is 14 and was inconstant in her sleep. Use of decongestants during pregnancy and the risk of birth defects. 2018;253(11):1452-1459. Heartgard for Dogs: How it Works and What it Does? Went from half a 75mg tab a day to two full tabs and then daily/nightly problems. Pasted as rich text. NADA 141-324. Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. After urinary incontinence is controlled, the lowest effective daily dose of Incurin should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. 14. Unfortunately as of a month ago it 21. This drug use to be for women until they started having strokes and dying. It is a multi-factorial problem and a variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence.
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proin vs incurin